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1

Age and life expectancy clocks based on machine learning analysis of mouse frailty

Schultz, Michael B., Kane, Alice E., Mitchell, Sarah J., MacArthur, Michael R., Warner, Elisa, Vogel, David S., Mitchell, James R., Howlett, Susan E., Bonkowski, Michael S., Sinclair, David A.

Journal:

Nature Communications

Year:

2020

File:

PDF, 2.11 MB

2020

2

A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner

Kane, Alice E, Keller, Kaitlyn M, Heinze-Milne, Stefan, Grandy, Scott A, Howlett, Susan E

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2018

Language:

english

File:

PDF, 996 KB

english, 2018

3

Approaches to the safety assessment of engineered nanomaterials (ENM) in food

Andrew Cockburn, Roberta Bradford, Neil Buck, Anne Constable, Gareth Edwards, Bernd Haber, Paul Hepburn, John Howlett, Frans Kampers, Christoph Klein, Marek Radomski, Hermann Stamm, Susan Wijnhoven, T

Journal:

Food and Chemical Toxicology

Year:

2012

Language:

english

File:

PDF, 956 KB

english, 2012

4

(Aminoalkyl)indole Isothiocyanates as Potential Electrophilic Affinity Ligands for the Brain Cannabinoid Receptor

Yamada, Koichiro, Rice, Kenner C., Flippen-Anderson, Judith L., Eissenstat, Michael A., Ward, Susan J., Johnson, M. Ross, Howlett, Allyn C.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 341 KB

english, 1996

5

The delivery of a survivors’ group for learning disabled women with significant learning disabilities who have been sexually abused

Nicholas Guy Peckham, Alan Corbett, Susan Howlett, Alan McKee, Sue Pattison

Journal:

British Journal of Learning Disabilities

Year:

2007

Language:

english

File:

PDF, 234 KB

english, 2007

6

Dysnatremia in Relation to Frailty and Age in Community-dwelling Adults in the National Health and Nutrition Examination Survey

Miller, Amanda J., Theou, Olga, McMillan, Miranda, Howlett, Susan E., Tennankore, Karthik K., Rockwood, Kenneth

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2016

Language:

english

File:

PDF, 756 KB

english, 2016

7

Animal models of frailty: current applications in clinical research

Kane, Alice, Hilmer, Sarah, Mach, John, Mitchell, Sarah, de Cabo, Rafael, Howlett, Susan

Journal:

Clinical Interventions in Aging

Year:

2016

Language:

english

File:

PDF, 404 KB

english, 2016

8

Electrophysiologic differences between normal and dystrophic avian muscle

Susan E Howlett, Theodore B Hoekman

Journal:

Experimental Neurology

Year:

1986

Language:

english

File:

PDF, 578 KB

english, 1986

9

Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty

Schultz, Michael B., Kane, Alice E., Mitchell, Sarah J., MacArthur, Michael R., Warner, Elisa, Vogel, David S., Mitchell, James R., Howlett, Susan E., Bonkowski, Michael S., Sinclair, David A.

Journal:

Nature Communications

Year:

2020

File:

PDF, 355 KB

2020

10

Rodent models of frailty and their application in preclinical research

Banga, Shubham, Heinze-Milne, Stefan D., Howlett, Susan E.

Journal:

Mechanisms of Ageing and Development

Year:

2019

File:

PDF, 430 KB

2019

11

”Voltage-activated Ca release” in rabbit, rat and guinea-pig cardiac myocytes, and modulation by internal cAMP

Ion A. Hobai, F. Chris Howarth, Vijay K. Pabbathi, Geoff R. Dalton, Jules C. Hancox, Jie-Quan Zhu, Susan E. Howlett, Gregory R. Ferrier, A. J. Levi

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1997

Language:

english

File:

PDF, 674 KB

english, 1997

12

Epidemiology of root rot caused byLeptosphaeria maculansinBrassica napuscrops

Susan J. Sprague, Barbara J. Howlett, John A. Kirkegaard

Journal:

European Journal of Plant Pathology

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

13

Adenosine preconditioning attenuates ischemia and reperfusion injury in young adult but not aged rat cardiomyocytes

Jessica H. Ferguson, Susan E. Howlett

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 46 KB

english, 2007

14

Frailty measure predicts incident dementia in the oldest old

Peers, Ruth, Beckett, Nigel, Warwick, Jane, Rockwood, Ken, Mitnitski, Arnold, Howlett, Susan, Bulpitt, Christopher

Journal:

Alzheimer's & Dementia

Year:

2015

Language:

english

File:

PDF, 105 KB

english, 2015

15

The impact of age and frailty on ventricular structure and function in C57BL/6

Feridooni, Hirad, Kane, Alice, Ayaz, Omar, Boroumandi, Ali, Polidovitch, N., Tsushima, Robert, Rose, Robert, Howlett, Susan

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2017

Language:

english

File:

PDF, 49 KB

english, 2017

16

The Impact of Ovariectomy on Calcium Homeostasis and Myofilament Calcium Sensitivity in the Aging Mouse Heart

Fares, Elias, Pyle, W. Glen, Ray, Gibanananda, Rose, Robert A., Denovan-Wright, Eileen M., Chen, Robert P., Howlett, Susan E., Beard, Nicole

Journal:

Year:

2013

Language:

english

File:

PDF, 2.11 MB

english, 2013

17

Overexpression of human β 2 -adrenergic receptors increases gain of excitation-contraction coupling in mouse ventricular myocytes

Grandy, Scott A., Denovan-Wright, Eileen M., Ferrier, Gregory R., Howlett, Susan E.

Journal:

AJP Heart and Circulatory Physiology

Year:

2004

Language:

english

File:

PDF, 416 KB

english, 2004

18

Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction

Ferrier, Gregory R., Howlett, Susan E.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2001

Language:

english

File:

PDF, 333 KB

english, 2001

19

Changes in excitation-contraction coupling in an isolated ventricular myocyte model of cardiac stunning

Louch, William E., Ferrier, Gregory R., Howlett, Susan E.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2002

Language:

english

File:

PDF, 547 KB

english, 2002

20

MEASURING CAREGIVER BURDEN ON A DEMENTIA SYMPTOM TRACKING WEBSITE

Stanley, Justin, Howlett, Susan E., Simpson, Amanda K., Rockwood, Kenneth

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 415 KB

english, 2018

21

Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice

Ghimire, Anjali, Bisset, Elise S., Howlett, Susan E.

Journal:

Biology of Sex Differences

Year:

2019

Language:

english

File:

PDF, 1.99 MB

english, 2019

22

P4-002: A FRAILTY INDEX BASED ON ROUTINELY COLLECTED LABORATORY SAFETY DATA PREDICTS DROPOUT IN ALZHEIMER DISEASE CLINICAL TRIAL SETTINGS

Dunn, Taylor, Stanley, Justin, Howlett, Susan E., Mitnitski, Arnold B., Rockwood, Kenneth

Journal:

Alzheimer's & Dementia

Year:

2019

Language:

english

File:

PDF, 104 KB

english, 2019

23

Density of Ryanodine Receptors is Increased in Sarcoplasmic Reticulum from Prehypertrophic Cardiomyopathic Hamster Heart

John L. Sapp, Susan E. Howlett

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1994

File:

PDF, 536 KB

1994

24

[3H]-nitrendipine binding in normal and cardiomyopathic hamster hearts: Modulation by temperature, verapamil and diltiazem

Susan E. Howlett, Tessa Gordon

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1990

Language:

english

File:

PDF, 1.66 MB

english, 1990

25

Unblock of the slow inward current induces the arrhythmogenic transient inward current in isolated guinea pig myocytes

Jonathan M Cordeiro, Susan E Howlett, Gregory R Ferrier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1991

Language:

english

File:

PDF, 117 KB

english, 1991

26

Approaches to monitoring biological outcomes for HPV vaccination: Challenges of early adopter countries

Charlene A. Wong, Mona Saraiya, Susan Hariri, Linda Eckert, Roberta I. Howlett, Lauri E. Markowitz, Julia M.L. Brotherton, Katy Sinka, Olga G. Martinez-Montañez, Susanne K. Kjaer, Eileen F. Dunne

Journal:

Year:

2011

Language:

english

File:

PDF, 181 KB

english, 2011

27

Ovariectomy enhances SR Ca2+ release and increases Ca2+ spark amplitudes in isolated ventricular myocytes

Elias Fares, Randi J. Parks, Jennifer K. MacDonald, Jeanne M.S. Egar, Susan E. Howlett

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2012

Language:

english

File:

PDF, 535 KB

english, 2012

28

Contractile properties of myocardium are altered in dystrophin-deficient mdx mice

John L Sapp, Jacques Bobet, Susan E Howlett

Journal:

Journal of the Neurological Sciences

Year:

1996

Language:

english

File:

PDF, 1.78 MB

english, 1996

29

Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature

MacIntyre, Jessica, Dong, Alex, Straiker, Alex, Zhu, Jiequan, Howlett, Susan E., Bagher, Amina, Denovan-Wright, Eileen, Yu, Dao-Yi, Kelly, Melanie E.M.

Journal:

European Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 3.70 MB

english, 2014

30

The Na+/Ca2+ exchange inhibitor SEA0400 limits intracellular Ca2+ accumulation and improves recovery of ventricular function when added to cardioplegia

Egar, Jeanne, Ali, Ahmad, Howlett, Susan E, Friesen, Camille Hancock, O’Blenes, Stacy

Journal:

Journal of Cardiothoracic Surgery

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

31

The impact of age and frailty on ventricular function before and after ischemia-reperfusion in C57BL/6 mice.

Feridooni, Hirad, Rose, Robert, Howlett, Susan

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2018

Language:

english

File:

PDF, 48 KB

english, 2018

32

P3-022: INDIVIDUALIZED SYMPTOM TRACKING WITH SYMPTOMGUIDE TM ALLOWS FOR CLINICALLY MEANINGFUL INTERPRETATION OF MMSE SCORE CHANGES IN A DEMENTIA DRUG TRIAL

Stanley, Justin, Dunn, Taylor, Howlett, Susan E., Rockwood, Kenneth

Journal:

Alzheimer's & Dementia

Year:

2019

File:

PDF, 521 KB

2019

33

Maladaptive changes associated with cardiac aging are sex-specific and graded by frailty and inflammation in c57bl/6 mice

Kane, Alice E, Bisset, Elise S, Heinze-Milne, Stefan, Keller, Kaitlyn M, Grandy, Scott A, Howlett, Susan E

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2020

File:

PDF, 1.28 MB

2020

34

Role of cAMP-dependent protein kinase A in activation of a voltage-sensitive release mechanism for cardiac contraction in guinea-pig myocytes

Gregory R. Ferrier, Jiequan Zhu, Isabel M. Redondo, Susan E. Howlett

Journal:

The Journal of Physiology

Year:

1998

Language:

english

File:

PDF, 611 KB

english, 1998

35

Angiotensin-converting enzyme responses following enalapril in the sodium deficient rat

Susan D. Longman, David R. Howlett

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 555 KB

english, 1986

36

Role of adenosine in the electrical and contractile responses of cardiac myocytes to simulated ischemia and reperfusion

Jonathan M. Cordeiro, Susan E. Howlett, Gregory R. Ferrier

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1992

Language:

english

File:

PDF, 116 KB

english, 1992

37

Findings of the UK National Audit Evaluating Image-guided or Image-assisted Liver Biopsy. Part II. Minor and Major Complications and Procedure-related Mortality

Howlett, David C., Drinkwater, Karl J., Lawrence, David, Barter, Susan, Nicholson, Tony

Journal:

Year:

2013

File:

PDF, 274 KB

2013

38

MEASURING CAREGIVER BURDEN ON A DEMENTIA SYMPTOM TRACKING WEBSITE

Stanley, Justin, Howlett, Susan E., Simpson, Amanda K., Rockwood, Kenneth

Journal:

Alzheimer's & Dementia

Year:

2018

File:

PDF, 415 KB

2018

39

Associations between a laboratory frailty index and adverse health outcomes across age and sex

Blodgett, Joanna M., Theou, Olga, Mitnitski, Arnold, Howlett, Susan E., Rockwood, Kenneth

Journal:

Year:

2019

Language:

english

File:

PDF, 380 KB

english, 2019

40

Frailty â A promising concept to evaluate disease vulnerability

Ribeiro, Ana Rita, Howlett, Susan E., Fernandes, Adelaide

Journal:

Mechanisms of Ageing and Development

Year:

2020

Language:

english

File:

PDF, 2.56 MB

english, 2020

41

Sarcoplasmic Reticulum Calcium Release Channels in Ventricles of Older Adult Hamsters

Nicholl, Peter A., Howlett, Susan E.

Journal:

Canadian Journal on Aging

Year:

2006

Language:

english

File:

PDF, 888 KB

english, 2006

42

Atrial structure, function and arrhythmogenesis in aged and frail mice

Jansen, Hailey J., Moghtadaei, Motahareh, Mackasey, Martin, Rafferty, Sara A., Bogachev, Oleg, Sapp, John L., Howlett, Susan E., Rose, Robert A.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.75 MB

english, 2017

43

COMPARISON OF A FRAILTY INDEX TOOL BASED ON CLINICAL ASSESSMENT WITH ONE BASED ON Routinely COLLECTED LABORATORY SAFETY DATA: LINKS BETWEEN FRAILTY, ADVERSE EVENTS, AND FUNCTION IN THE SETTING OF AN ALZHEIMER’S DISEASE CLINICAL TRIAL

Stanley, Justin, Dunn, Taylor, Howlett, Susan E., Mitnitski, Arnold B., Rockwood, Kenneth

Journal:

Alzheimer's & Dementia

Year:

2018

File:

PDF, 118 KB

2018

44

Effect of age on cardiac excitation–contraction coupling

Elias Fares, Susan E Howlett

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2010

Language:

english

File:

PDF, 277 KB

english, 2010

45

The age-related decrease in catecholamine sensitivity is mediated by ß1-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats

Spring R. Farrell, Susan E. Howlett

Journal:

Mechanisms of Ageing and Development

Year:

2008

Language:

english

File:

PDF, 852 KB

english, 2008

46

Pediatric Cardioplegia Strategy Results in Enhanced Calcium Metabolism and Lower Serum Troponin T

J. Darcy O'Brien, Susan E. Howlett, Hayley J. Burton, Stacey B. O'Blenes, D. Sharon Litz, Camille L. Hancock Friesen

Journal:

The Annals of Thoracic Surgery

Year:

2009

Language:

english

File:

PDF, 886 KB

english, 2009

47

Role of voltage-sensitive release mechanism in depression of cardiac contraction in myopathic hamsters

Howlett, Susan E., Xiong, Wei, Mapplebeck, Cindy L., Ferrier, Gregory R.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1999

Language:

english

File:

PDF, 244 KB

english, 1999

48

AGE-RELATED DEFICIT ACCUMULATION AND THE DISEASES OF AGEING

Rockwood, Kenneth, Howlett, Susan E

Journal:

Mechanisms of Ageing and Development

Year:

2019

Language:

english

File:

PDF, 783 KB

english, 2019

49

Calcium sparks in mouse ventricular myocytes at physiological temperature

Ferrier, Gregory R., Smith, Robin H., Howlett, Susan E.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2003

Language:

english

File:

PDF, 521 KB

english, 2003

50

Alterations in ventricular K ATP channel properties during aging

Bao, Li, Taskin, Eylem, Foster, Monique, Ray, Beevash, Rosario, Rosa, Ananthakrishnan, Radha, Howlett, Susan E., Schmidt, Ann M., Ramasamy, Ravichandran, Coetzee, William A.

Journal:

Year:

2013

Language:

english

File:

PDF, 470 KB

english, 2013

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